Companion to the Count by Melissa Kendall

Taken together, these findings suggest that circulating proteins measured at early stages of disease progression are reasonably accurate predictors of COVID-19 severity. Proteins selected from different COVID-19 severity were enriched for cytokine and cytokine receptors, but more than half of the enriched pathways were not immune-related. Selecting 92 proteins from the 4701 unique protein abundances improved the AUC to 88% in the training cohort, which remained relatively stable in the testing cohort at 86%, suggesting good generalizability. For severe COVID-19, a baseline model including age and sex provided an area under the receiver operator curve (AUC) of 65% in the test cohort. We then trained prediction models including protein abundances and clinical risk factors to predict COVID-19 severity in 417 subjects and tested these models in a separate cohort of 569 individuals. To approach this problem, we measured 4701 circulating human protein abundances in two independent cohorts totaling 986 individuals. Predicting COVID-19 severity is difficult, and the biological pathways involved are not fully understood. Itamar Sela, Coren Lahav, Ben Yellin, Yehonatan Elon, Michal HarelĬirculating proteins to predict COVID-19 severity When not working Geoff enjoys running, hiking and sampling the local wine and cuisine.Analytical validation of the PROphet computational model for clinical benefit prediction and decision-making tool in metastatic NSCLC

Geoff now operates as a mobile cardiologist seeing cases in multiple clinics and cities throughout Australia.

Geoff then spent 12 months working for Dr Richard Woolley in Melbourne before deciding to begin his own cardiology referral business.

In 2012 Geoff completed a 1-year rotating internship at the University of Queensland Veterinary Training Hospital followed by a 3-year ECVIM approved cardiology residency training program at the University of Sydney Veterinary Teaching Hospital under the supervision of European-boarded cardiology specialist Dr Niek Beijerink.Įarly in 2017 Geoff successfully completed the examination to obtain Diplomate status in the European College of Veterinary Internal Medicine – Companion Animals, in the subspecialty of Cardiology. Veterinary Cardiologist (Heart Specialist)ĭr Geoff Nicolson completed his undergraduate veterinary training at the University of Queensland.

Companion to the Count by Melissa Kendall